Short-term effect of topical 2% Dorzolamide, 0.5% Timolol and 0.005% Latanoprost on the intra ocular pressure and on the anterior segment architecture in normotensive dogs: a prospective study
A Poinsard, T Bastogne, PF Isard, T Dulaurent and O Balland
*Centre Hospitalier Veterinaire Lorrainevet, Ludres, France; †Universite de Lorraine, CRAN, UMR 7039, Vandoeuvre-l es-Nancy, France; CNRS, CRAN, UMR 7039, Vandoeuvre-l es-Nancy, France; §INRIA, BIGS, France; ¶Centre Hospitalier V et erinaire St Martin, Saint-Martin Bellevue, France
Purpose: To evaluate the effect of three different antiglaucomatous drugs on the biometrics of the anterior segment in normotensive dogs. Material/Methods: Three groups of 15 clini- cally healthy randomly selected dogs received one single molecule on the right eye during 7 days (Group 1: 2% Dorzolamide BID, Group 2: 0.5% Timolol BID, Group 3: 0.005% Lata- noprost SID). Left eyes received no treatment and were used as controls. Complete ophthalmic examination, IOP measurement and anterior segment assessment by Ultrasound Biomi- croscopy (UBM) were performed in the same conditions at day 1 and day 7, on both eyes. Eight anatomical parameters of the anterior segment were evaluated: the geometric iridocorneal angle (ICA) – formed by the plane of the iris root and the internal corneoscleral limbus – the width of the opening of the ciliary cleft (CC), the width of the mid-CC, the length of the CC, the anterior chamber (AC) depth (distance between the corneal endothelium and the anterior lens capsule), the central and peripheral corneal thicknesses, and the distance between the ante- rior lens capsule and the internal corneoscleral limbus. Results: A significant decrease of IOP was observed for Dorzolamide (8.4%), Timolol (6.8%) and Latanoprost (29%). Furthermore, with Dorzolamide, the width of the opening of the CC was significantly increased (7.2%) while the peripheral corneal thickness was slightly decreased (2.7%). None of the other anatomical parameters were statistically modified. Discussion: The use of these antiglaucomatous agents leads to significant IOP decrease, without any significantly variation of the anterior segment architecture in normotensive dogs. Support/Interest disclosure: None.